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WHERE DOES THE MONEY GO?

FINDING TREATMENT FOR RIBOCICLIB RESISTANT BREAST CANCER USING PERSONALISED MEDICINE AND BIOSENSOR TECHNOLOGY

2021 - 2023

INSTITUTION:

The Garvan Institute of Medical Research

 

CHIEF RESEARCHER:

Prof. Paul Timpson

Our ultimate goal is to have the design of an early phase clinical trial conceptually established and pre-clinically validated within the duration of this grant.

Advanced estrogen receptor positive (ER+) breast cancer is responsible for more than 50% of breast cancer deaths. CDK4/6 inhibitors, such as Ribociclib, have been the most effective drugs to be released for ER+ patients in the last 10 years. They double survival, are orally administered, and have few side effects. But we have no way to treat patients once their cancer becomes resistant to CDK4/6 inhibitors and the cancer recurs. A personalised medicine approach to improve drug targeting in this setting is therefore critical. Using cutting-edge imaging technology and 3D patient-derived models that mimic the disease, we can map areas of poor drug response within distinct regions of tumours. Here, we will counteract factors driving drug resistance in these areas.

FINDING TREATMENT FOR RIBOCICLIB RESISTANT BREAST CANCER USING PERSONALISED MEDICINE AND BIOSENSOR TECHNOLOGY

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Love Your Sister is Australia's hardest-working cancer vanquishing charity, and since its inception in 2012 has raised $20M for medical research.

 

Founded by Gold Logie-winning actor and Victorian Australian of the Year 2018, Samuel Johnson OAM, Love Your Sister is a million-strong village of everyday Aussies committed to vanquishing cancer with hard science and the best new technologies. Love Your Sister supports precision treatment for ALL cancer patients, whatever the cancer, regardless of location, age, income, or status. We strive for the right treatment for every cancer patient, first time, every time.

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