WHERE DOES THE MONEY GO?

IDENTIFYING TARGETS ON MYELOID CELLS TO DESIGN PERSONALISED COMBINATION IMMUNOTHERAPIES FOR TRIPLE-NEGATIVE BREAST CANCER

2021 - 2023

INSTITUTION:

CHIEF RESEARCHER:

Olivia Newton-John Cancer Research Institute (ONJCRI) & La Trobe University

Prof. Robin Anderson

Targeting pro-tumour immune cells to improve response to immunotherapy for triple-negative breast cancer patients.

Immunotherapy has shown remarkable success in some types of cancer, especially melanoma. While a modest proportion of patients with triple-negative breast cancer (TNBC) respond well to a form of immunotherapy, called anti-PD-L1 therapy, the majority do not respond - probably because they have too few or inactive lymphocytes (cancer cell-killing immune cells) in the tumour. We have evidence that neutrophil-like cells that normally fight bacterial infections can turn into another type of cell (G-MDSC) in a cancer patient, which in turn helps the cancer grow and spread. By targeting these G-MDSC, we hope to harness the benefits of immunotherapy for many more patients with TNBC. To achieve this goal, we will test three new therapies for their ability to inhibit the G-MDSC population without affecting the actual neutrophils needed to fight infection. The outcome will be a combination therapy targeting G-MDSC cells and PD-L1 that will increase the reach and response to immunotherapy in TNBC patients.

Olivia Newton-John Cancer Research Institute (ONJCRI) & La Trobe University
Olivia Newton-John Cancer Research Institute (ONJCRI) & La Trobe University
IDENTIFYING TARGETS ON MYELOID CELLS TO DESIGN PERSONALISED COMBINATION IMMUNOTHERAPIES FOR TRIPLE-NEGATIVE BREAST CANCER